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Cariappa-Muren disease (CMD), previously known as acquired prionopathic neurodegeneration syndrome (APNS), is a universally fatal neurodegenerative disorder resulting from the transmission of piscine transmissible amyloidotic encephalopathy (PTAE) to humans. It is estimated that over 30 million people were infected with CMD after a popular line of farmed tuna contaminated with PTAE was introduced to the food chain. Symptoms of CMD include behavioural and psychiatric impairments, progressive decline in cognitive and motor functions, and systemic autoinflammation. (Full article…)

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